ESTUDO COMPARATIVO DOS EFEITOS DA DEXMEDETOMIDINA E XILAZINA EM BOVINOS SUBMETIDOS A LAVADO BRONCOSCÓPICO
A xilazina e a dexmedetomidina são
fármacos do grupo dos agonistas de receptores
α-2 adrenérgicos. Essas drogas fornecem
sedação ao agir em receptores adrenérgicos
centrais, causando miorrelaxamento e
analgesia para procedimentos médicos
e cirúrgicos. Diante do fato que as doses
recomendadas de xilazina para bovinos podem
causar o decúbito dos mesmos e que não
há relato do uso da dexmedetomidina, em
bovinos este estudo propôs avaliar a eficiência
da xilazina na dose de 0,01mg/kg e da
dexmedetomidina na dose de 0,001mg/kg para
a coleta de lavado broncoalveolar em bovinos.
Para tanto foram utilizados cinco novilhas da
raça Jersey, saudáveis , sedadas com xilazina
e dexdetomidina, por via intravenosa, pelo
delineamento simples reverso. Foram avaliados
os parâmetros vitais: frequência cardíaca (FC),
temperatura (T), pressão arterial sistólica (PAS)
e movimentos ruminais (MR) além disso, grau
de sedação, reflexo de deglutição e de perda
de nocicepção a passagem do broncoscopio
na narina. Como resultado, verificou-se que
a dexmedetomidina causou diminuição da
frequência cardíaca, dos movimentos ruminais
dos bovinos e menor perda do reflexo de
deglutição e de perda de nocicepção, enquanto
que a xilazina apenas reduziu os movimentos
ruminais, concluindo-se, portanto, que a
xilazina nesta dose, foi mais eficiente para o
procedimento que a dexmedetomidina.
ESTUDO COMPARATIVO DOS EFEITOS DA DEXMEDETOMIDINA E XILAZINA EM BOVINOS SUBMETIDOS A LAVADO BRONCOSCÓPICO
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DOI: 10.22533/at.ed.86919260412
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Palavras-chave: ruminantes, sedação, alometria.
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Keywords: Xylazine and dexmedetomidine are drugs of the agonist group of 2-adrenergic A produção do Conhecimento nas Ciências Agrárias e Ambientais 3 Capítulo 12 128 receptors. These drugs provide sedation upon acting on adrenergic receptors, causing myorelaxation and analgesia for medical and surgical procedures. Given the fact that the recommended doses of xylazine for cattle may cause the decubitus position change and that there are no reports of the use of dexmedetomidine in cattle this study was designed to evaluate the efficiency of xylazine in the dose of 0.01 mg/kg and of dexmedetomidine at a dose of 0.001mg/kg for the collection of bronchoalveolar lavage in cattle. Therefore, five heifers were used of the Jersey breed, healthy, sedated with xylazine and dexmedetomidine, intravenously, by simple reverse design. Vital parameters were evaluated: heart rate (HR), rectal temperature (RT), systolic blood pressure (SBP) and ruminal movements (MR) in addition, the degree of sedation, swallowing reflex and loss of nociception and passage of bronchoscope in the nostril. As a result, it was found that dexmedetomidine decreases the heart rate, the ruminal movements of cattle and lower swallowing reflex and loss of nociception, while xylazine only reduced the ruminal. movements, it can be concluded, therefore, that xylazine at the dose aforementioned, was more efficient for the procedure than dexmedetomidine.
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Abstract:
Xylazine and dexmedetomidine
are drugs of the agonist group of 2-adrenergic
A produção do Conhecimento nas Ciências Agrárias e Ambientais 3 Capítulo 12 128
receptors. These drugs provide sedation upon acting on adrenergic receptors, causing
myorelaxation and analgesia for medical and surgical procedures. Given the fact
that the recommended doses of xylazine for cattle may cause the decubitus position
change and that there are no reports of the use of dexmedetomidine in cattle this study
was designed to evaluate the efficiency of xylazine in the dose of 0.01 mg/kg and of
dexmedetomidine at a dose of 0.001mg/kg for the collection of bronchoalveolar lavage
in cattle. Therefore, five heifers were used of the Jersey breed, healthy, sedated
with xylazine and dexmedetomidine, intravenously, by simple reverse design. Vital
parameters were evaluated: heart rate (HR), rectal temperature (RT), systolic blood
pressure (SBP) and ruminal movements (MR) in addition, the degree of sedation,
swallowing reflex and loss of nociception and passage of bronchoscope in the nostril.
As a result, it was found that dexmedetomidine decreases the heart rate, the ruminal
movements of cattle and lower swallowing reflex and loss of nociception, while xylazine
only reduced the ruminal. movements, it can be concluded, therefore, that xylazine at
the dose aforementioned, was more efficient for the procedure than dexmedetomidine.
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Número de páginas: 15
- Desiree Vera Pontarolo
- Heloisa Godoi Bertagnon
- Alessandra Mayer Coelho
- Bruna Artner
- Natalí Regina Schllemer
- sharlenne LEITE DA SILVA MONTEIRO
