A EFICÁCIA DA ESPIRAMICINA NO TRATAMENTO DA TOXOPLASMOSE CONGÊNITA THE EFFECTIVENESS OF SPIRAMYCIN IN THE TREATMENT OF CONGENITAL TOXOPLASMOSIS
A EFICÁCIA DA ESPIRAMICINA NO TRATAMENTO DA TOXOPLASMOSE CONGÊNITA THE EFFECTIVENESS OF SPIRAMYCIN IN THE TREATMENT OF CONGENITAL TOXOPLASMOSIS
-
DOI: https://doi.org/10.22533/at.ed.35324080812
-
Palavras-chave: Espiramicina; Toxoplasmose Congênita; Toxoplasma gondii.
-
Keywords: Spiramycin; Congenital toxoplasmosis; Toxoplasma gondii.
-
Abstract: Introduction: Toxoplasmosis is a zoonosis with wide geographical distribution and in the animal kingdom, caused by the intracellular protozoan Toxoplasma gondii. In its reproductive cycle, the parasite can infect humans as an intermediate host and feline animals as a definitive host. Congenital toxoplasmosis occurs when the pregnant woman transmits the parasite to the fetus, causing serious consequences such as cerebral calcifications, chorioretinitis, hydrocephalus and premature abortion. One of the drugs used in the treatment of congenital toxoplasmosis is spiramycin. Objective: The objective of this work was to carry out a literature review on the efficacy of the drug spiramycin when used in the treatment of congenital toxoplasmosis. Methodology: Base-search databases were used; bdtd.ibict and google academic for consulting scientific articles in addition to reference literature in parasitology and pharmacology. Through the keywords “spiramycin”; “Toxoplasma gondii” and “congenital toxoplasmosis”, works that have a direct relationship with congenital toxoplasmosis and treatment using the drug spiramycin were selected. Theoretical framework: The treatment of congenital toxoplasmosis using drugs is still a controversial topic and lacks certain information due to the few studies with clinical trials. Spiramycin is an antibiotic of the pharmacological class of macrolides obtained through the fermentation process of fungi of the species Streptomyces ambofaciens. Conclusion: The use of spiramycin in the treatment of congenital toxoplasmosis is essential because it avoids transmission of the parasite to the developing fetus and does not have toxic and teratogenic effects, although it is not effective against all forms of the parasite.
- Robson Alfredy da Silva Sousa
- Tania Rocha dos Santos
- Beatriz Camargo