VIRULENCE FACTORS OF Escherichia coli AS ANTIGENS IN VACCINES AGAINST URINARY TRACT INFECTION.

• DOI: 10.22533/at.ed.9322321037

• Palavras-chave: -

• Keywords: Escherichia coli; virulence factors; vaccine antigens; urinary tract infections

• Abstract:

  Escherichia coli is the main agent of urinary tract infection (UTI) among uropathogens isolated of community-acquired or hospital infections around the world.

  Because, in general, UTI treatment is empirical, it is a medical condition in which both antibiotic prescription and consumption are high, generating strong social, economic, and people health impact.

  As the antibiotic therapy of UTI is directly associated with the increase of antimicrobial resistance rates of uropathogens, including E. coli, alternative strategies to antibiotic use to treat or prevent UTI, are urgent.

  A promising option is the development of vaccines against UTI using E. coli

  virulence factors as antigens.