VIAS DE ESTRESSE OXIDATIVO ATIVADAS NO COMPORTAMENTO TIPO DEPRESSIVO E ANSIOSO
VIAS DE ESTRESSE OXIDATIVO ATIVADAS NO COMPORTAMENTO TIPO DEPRESSIVO E ANSIOSO
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DOI: https://doi.org/10.22533/at.ed.9832516094
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Palavras-chave: Defesas antioxidantes; Espécies reativas de oxigênio; Transtornos de humor.
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Keywords: Antioxidant defenses; Reactive oxygen species; Mood disorders.
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Abstract: Oxidative stress, resulting from the imbalance between reactive oxygen species and antioxidant defenses, influences the vulnerability of the nervous system, given the high cerebral energy demand and its limited antioxidant capacity. In depressive and anxious disorders, increased ROS, mitochondrial dysfunction, neuroinflammation, and alterations in transcription pathways are observed, which in turn lead to cellular damage, impaired neuroplasticity, and neurotransmitter dysregulation. Clinical evidence shows elevated oxidative and inflammatory markers and reduced antioxidants, findings that tend to normalize after antidepressant treatment. In this context, natural and synthetic antioxidants, diets rich in antioxidant compounds, and classical drugs (SSRIs, lithium) emerge as promising strategies to restore redox balance and attenuate depressive and anxious symptoms, although challenges remain regarding standardization, adherence, and therapeutic personalization
- Geovana Vieira Jacques
- Gabriela Escalante Brites
- Laura Smolski dos Santos
- Gênifer Erminda Schreiner
- Glaura Paulo Fagundes Olivier
- Fernanda Comarú da Silva de Mello
- Eduarda de Moura Ferreira
- Carolina Pereira de Oliveira
- Camila Berny Pereira
- Alice Garcia Braum
- Jaciara Esteveni Cunha Acosta
- Danielle de Menezes Amaral
- Raiane Feiffer Grohe
- Emanuelle Malvassora
- Mohammad Prudêncio Mustafá
- Erick Trindade Lopes
- Silvia Muller de Moura Sarmento
- Vanusa Manfredini
