USO DE PLANTAS MEDICINAIS COM ENFOQUE NO TRATAMENTO DA ESTRONGILOIDÍASE: REVISÃO NARRATIVA

• DOI: https://doi.org/10.22533/at.ed.93824270312

• Palavras-chave: helmintíase, estrongiloidíase, fitoterapia.

• Keywords: helminthiasis, strongyloidiasis, herbal medicine

• Abstract: Phytotherapy is an area of non-conventional medicine that aims to use plants present in nature as sources of treatment for various diseases, including parasitic infections. These diseases are considered an important public health problem worldwide. Strongyloidiasis is a helminthiasis caused by Strongyloides stercoralis, which can cause anything from an asymptomatic infection to the death of the individual in cases where the disease spreads. The therapeutic protocols usually applied to treat strongyloidiasis include albendazole, mebendazole, thiabendazole and ivermectin, which are showing parasitic resistance due to indiscriminate use. Therefore, the search for new bioactives against strongyloidiasis has become essential. This study aimed to search, list and explain the use of various plants and compounds that showed anthelmintic activity with a focus on infections by Strongyloides venezuelensis and Strongyloides stercoralis. This is a narrative review work, where studies were selected from the PubMed, SciELO and LILACS databases using the following descriptors: “medicinal plants, protozoology, helminthology parasites, human infections”, published in the 2000-2024 time series. The inclusion criteria for selecting articles were all that covered the chosen topic. The research identified some studies that covered the topic, listing several plants with anthelmintic potential against species of the genus Strongyloides. In these studies, the names of plants and compounds that showed an effect against infection by Strongyloides sp. However, it is important to highlight the need for other studies with a deeper search for the mechanisms of action of these compounds, as well as the toxicity they offer, so that a cost-benefit analysis can be carried out in the use of these compounds as future principles. assets for the creation of new medicines. It is concluded that there is a great diversity of plants with anthelmintic potential against strongyloidiasis and that it is extremely important that new studies be carried out.