TRATAMENTO DIETÉTICO CETOGÊNICO DE EPILEPSIA REFRATÁRIA EM CRIANÇAS: REVISÃO NARRATIVA
TRATAMENTO DIETÉTICO CETOGÊNICO DE EPILEPSIA REFRATÁRIA EM CRIANÇAS: REVISÃO NARRATIVA
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DOI: https://doi.org/10.22533/at.ed.48824050215
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Palavras-chave: Epilepsia Refratária. Crise Convulsiva. Terapia Alternativa. Dietoterapia. Pacientes Pediátricos.
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Keywords: Refractory Epilepsy. Convulsive Crisis. Alternative Therapy. Diet Therapy. Pediatric Patient.
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Abstract: Epilepsy is a neurological condition due to a genetic abnormality or acquired brain damage, characterized by regular and disparate convulsive episodes. Refractory epilepsy, a drug-resistant category, is very common in children and lacks alternative treatments. Therefore, the ketogenic diet - a diet rich in lipids, moderate in proteins and low in carbohydrates - appears as a nutritious and less invasive alternative for pediatric patients with this condition. The objective of this article was evaluate and discuss the efficiency of ketogenic dietary treatment in children with refractory epilepsy, as well as its action mechanism. A narrative review of studies was carried out in the public and open access databases PubMed/Medline and SciELO, using the indexing terms Ketogenic Diet, Refractory Epilepsy and Children, associated with the Boolean Connectors AND, OR and NOT, between the years from 2002 to 2020, restricted to Portuguese and English languages. Abstracts of presentations and meetings, editorials, review articles, studies without enough data, and other articles that did not meet the inclusion criteria: articles that included in their primary resolution the effectiveness of ketogenic dietary treatment in children, from 1 year to 13 years, with refractory epilepsy, were excluded. When carrying out the advanced search, 675 articles were identified in PUBMED/Medline and 13 in SciELO. Then, 11 articles were selected according to the established inclusion and exclusion criteria. Analyzing the selected studies, 8 positive results and 7 adverse effects were found in pediatric patients undergoing ketogenic dietary treatment. This research concluded that the ketogenic diet is a therapy used to treat children with refractory epilepsy. Its function is to modulate neurotransmitters through the production of ketone bodies, controlling epileptic seizures and proving beneficial to children who do not respond adequately to conventional medications, despite the existence of reversible adverse effects.
- Yasmin Czervenny Schoemberger
- Luiza Maria Pereira
- Maria Augusta Pacheco Jacobsen
- Beatriz Vicenzi Rocha
- Rafaella Smaniotto Santana
- Luísa Garbossa
- Ana Luisa Trentini Bittencourt
- Sophia Lugarini
- Lorenzo De Santiago Biesuz
- Selton Eliezer Steniski
- Rafael Schmid Scapini
- João Victor Hertel Fiates
- Isabelli Zeitz de Castro