THERAPEUTIC APPROACHES WITH STEM CELLS TO CURE HIV

• DOI: .https://doi.org/10.22533/at.ed.03124170525

• Palavras-chave: CCR5-32.Patient from Berlin. HIV + Leukemia. HIV cure. Stem cells. HIV.

• Keywords: CCR5-32.Patient from Berlin. HIV + Leukemia. HIV cure. Stem cells. HIV.

• Abstract: The Human Immunodeficiency Virus (HIV) is responsible for the development of Acquired Immunodeficiency Syndrome (AIDS), a disease which, despite treatment, there is currently no cure for. However, some tests have been carried out on patients with hematological diseases such as leukemia. Stem cell transplantation is a treatment that allows the virus to go into remission and then be eliminated. The treatment involves transplanting stem cells from donors who are homozygous for the mutation in the CCR5 gene in delta 32, because CCR5Δ32 is naturally resistant to the virus, as it causes a deletion of the CCR5 receptors in the cells, making it possible for the virus not to enter the body's cells, leaving the individual HIV-free. Based on this information, the aim of this work is to demonstrate new possibilities for treatment and possible exhumation of the HIV/AIDS virus through stem cell transplantation.