Analysis of β-Lactamase Proteins Through Computational Chemistry Techniques

• DOI: https://doi.org/10.22533/at.ed.0112419073

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• Abstract: Given the substantial implications of bacterial resistance for public health, it is imperative to comprehensively understand the mechanisms driving this resistance. Our aim is to undertake a taxonomical exploration of bacterial β-lactamases, with the goal of establishing a novel classification framework rooted in their molecular makeup, divergent from existing approaches. We developed a phylogenetic tree of clinically relevant bacterial β-lactamases utilizing their molecular sequences, subsequently generating a cladogram to unravel the distinctive traits of the various families and subfamilies.