SUPLEMENTAÇÃO COM EXTRATO DA LARANJA MORO (Citrus sinensis (L) Osbeck) EM RATOS OBESOS MELHORA OS PARÂMETROS BIOQUÍMICOS E HORMONAIS

• DOI: https://doi.org/10.22533/at.ed.3952424107

• Palavras-chave: parâmetros bioquímicos, obesidade, extrato laranja moro.

• Keywords: biochemical parameters, obesity, moro orange extract

• Abstract: Chronic metabolic diseases, such as obesity, are considered a public health problem in Brazil and around the world. As it is a multifactorial disease, the treatment of obesity involves changes in eating habits and physical activity. In this context, Citrus sinensis L. Osbeck, the moro orange, appears as a functional food rich in antioxidants and vitamin C. Studies suggest that functional foods can help control diseases, therefore, the objective of this work was to determine biochemical markers in rats Wistar obese males supplemented with orange extract (Citrus sinensis L. Osbeck).  We used 25 male Wistar rats randomly divided into 5 groups (n=5): control group, obese group, Orlistat® group, moro orange extract group and the moro orange extract + Orlistat® group. With the exception of the control group, the other groups received a high-calorie diet, a cafeteria diet to induce obesity for nine weeks. After obesity induction, the extract was administered at a dose of 7.15 mg/kg, and the reference medication (Orlistat®) at a dose of 1.72 mg/kg, by gavage, daily at the same time for four weeks. treatment. The animals were euthanized on the 94th day (ninety-fourth) of treatment, where whole blood was collected by cardiac puncture, and blood centrifugation was performed to obtain serum for biochemical markers. The results found show that moro orange extract was able to reduce the levels of glucose, total cholesterol, LDL, triglycerides and adiponectin, as well as increasing the levels of HDL and leptin. Thus, Citrus sinensis L. Osbeck extract appears to be a good alternative for controlling biochemical parameters altered in obesity.