SÍNDROME PÓS-COVID-19 AGUDA E PROGRESSÃO DA SARCOPENIA NO PROCESSO AVANÇADO DE ENVELHECIMENTO
SÍNDROME PÓS-COVID-19 AGUDA E PROGRESSÃO DA SARCOPENIA NO PROCESSO AVANÇADO DE ENVELHECIMENTO
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DOI: 10.22533/at.ed.96123280812
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Palavras-chave: Síndrome Pós-COVID-19 aguda. Sarcopenia. Saúde do Idoso. Estresse Oxidativo. Imunossenescência.
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Keywords: Acute Post-COVID-19 Syndrome. Sarcopenia. Elderly Health. Oxidative stress. Health education.
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Abstract: Sarcopenia is a musculoskeletal disorder that results from several factors such as low frequency of physical activity and poor diet, being highly prevalent in the elderly population. Acute Post-COVID-19 Syndrome (PACS) is characterized by the continuity of symptoms of SARS-CoV-2 infection such as fatigue, dyspnea and muscle weakness even after total remission of the disease. Studies have shown the relationship between PACS and sarcopenia, impacting, above all, the population in an advanced aging process, from motor performance to psychiatric disorders. The accumulation of reactive oxygen species occurs physiologically with advancing age and may have its control mechanisms deregulated in conditions of exhaustion, such as in infectious processes, which interfere with mitochondrial integrity, leading to a state of oxidative stress that is important in the progression of sarcopenia. The immune potential of individuals changes over time influenced by genetics, lifestyle and environmental factors. Immunosenescence represents the set of immunological disorders such as the gradual increase in levels of inflammatory cytokines and lower functionality of T cells. During the acute phase of the infection, especially in a senescent organism, there is an exacerbation of the inflammatory response causing persistent damage such as loss of body weight, dehydration and reduced muscle volume. As a therapeutic perspective for the rehabilitation of muscle mass and function, adapted physical resistance exercises and adequate nutritional replacement are recommended, acting both in the maintenance and regeneration of muscle mass and in the reduction of oxidizing agents and inflammatory mediators, thus improving the clinical condition and quality of life of the elderly.
- Helamã Moraes dos Santos
- Keyllor Nunes Domann
- André Costa
- Betina Drehmer da Rosa
- Josiano Guilherme Puhle
- Fabiana Brum Haag
- DEBORA TAVARES DE RESENDE E SILVA
- Débora Tavares de Resende e Silva