SÍNDROME DE SHEEHAN E DISFUNÇÕES ENDÓCRINAS
SÍNDROME DE SHEEHAN E DISFUNÇÕES ENDÓCRINAS
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DOI: https://doi.org/10.22533/at.ed.07624120618
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Palavras-chave: Gravidez, Hemorragia pós-parto, Hipopituitarismo, Síndrome de Sheehan, Necrose Pituitária.
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Keywords: Pregnancy, Postpartum hemorrhage, Hypopituitarism, Sheehan's Syndrome, Pituitary Necrosis.
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Abstract: ABSTRACT: INTRODUCTION: Sheehan's syndrome is a condition characterized by secondary hypopituitarism due to pituitary necrosis, as a consequence of severe hypotension caused by postpartum hemorrhage. Furthermore, it is still a syndrome little diagnosed by many doctors, which causes the destruction of a gland of utmost importance for endocrine metabolism that regulates the synthesis and release of a range of hormones such as LH, FSH, ADH, OCYTOCIN, PROLACTIN , ACTH, GH AND TSH. METHODOLOGY: The LILACS, SciELO, PubMed databases were consulted using terms such as “Sheehan Syndrome”, “Pregnancy”, “Postpartum Hemorrhage”, “Pituitary Necrosis” and “Hypopituitarism”. Articles from 2008 to 2023 were included, in Portuguese, English and Spanish, that addressed strategies in the context of Sheehan Syndrome. RESULTS: In this context, it presents symptoms corresponding to decreased hormone levels. In clinical evaluation, it can be seen that ACTH deficit contributes to extreme fatigue, weakness and paleness. As for TSH, it impacts cold intolerance, constipation, bradycardia and weight gain. Related to FSH and LH, they interfere with amenorrhea, infertility and breast atrophy. HC deficiency causes a decrease in muscle mass, an increase in visceral fat and premature atherosclerosis. Finally, the decrease in prolactin causes hypolactia or agalactia. Therefore, when understanding the relevance of these hormones in the body, their absence contributes to a decline in metabolism and consequently the quality of life of women who suffer from this endocrine disorder. CONCLUSION: Sheehan Syndrome is a complex medical condition that presents a wide variety of symptoms, which can have a significant impact on women's health. Furthermore, this syndrome is associated with several complaints resulting from multiple hormonal deficiencies and the difficulty in establishing a connection between the onset of symptoms and the time of birth, making diagnosis challenging. However, appropriate treatment can improve quality of life and reduce health risks, in addition to minimizing clinical aspects.
- Nathalia Sofia Mayer Ceron
- Annalisa Naome Eda Nezu
- Isabela Olivo Pires
- Julia Borges Barbero
- Larissa Paula Pinho Simão
- Luiz Eduardo Piovezan Kasprzak Nascimento
- Tathiana D'Heronville Pires
- Valentine Ferlin