Citrus growers primarily use chemical control to keep pest populations below the economic threshold. However, the inappropriate use of pesticides results in undesirable side effects, such as population outbreaks of secondary pests and the evolution of resistance in populations. The evolution of pest resistance to pesticides has been considered one of the highest threats to the implementation of integrated pest management (IPM) programs. The citrus crop is home to numerous arthropods, including several species of pest mites. Citrus mites are basically controlled worldwide with chemical acaricide applications (Van Leeuwen et al., 2010). However, the continuous use of the same active ingredient can increase the frequency of resistant individuals and compromise the efficiency of products (Omoto & Alves, 2004). Failures in the control of mites after acaricide applications are frequent in the Brazilian citriculture and have been reported for several decades. In this scenario, this chapter addresses the main cases of pest mite resistance in citrus to pesticides published in scientific journals.