RELAÇÃO ENTRE O TRATAMENTO COM BISFOFONATOS E O SURGIMENTO DE OSTEONECROSE NOS MAXILARES: REVISÃO DE LITERATURA

• DOI: https://doi.org/10.22533/at.ed.931132501088

• Palavras-chave: Bisphosphonates; Osteonecrosis of the jaws;

• Keywords: Bisfosfonatos; Osteonecrose dos maxilares;

• Abstract: Bisphosphonates are a group of drugs widely used to treat patients diagnosed with bone metastases and individuals with metabolic disorders that accelerate bone loss, such as osteoporosis. This condition results from an imbalance between bone formation and resorption, resulting from the imbalanced activity of osteoblasts and osteoclasts. The main action of bisphosphonates is related to the inhibition of bone resorption, promoting osteoblastic activity and directly interfering with osteoclast function by reducing their recruitment and stimulating apoptosis of these cells. In recent years, an association has been observed between prolonged bisphosphonate use and the development of aseptic osteonecrosis of the jaw, especially in patients undergoing surgical procedures such as tooth extractions. This study analyzes the relationship between bisphosphonate use and the occurrence of osteonecrosis of the jaw. The overall objective is to understand the possible correlation between the administration of these medications and the development of osteonecrosis in this region. The methodology adopted consists of a literature review, based on national and international sources, including scientific articles, monographs, books, dissertations, academic journals, and specialized databases. It was found that, to date, there is no consensus in the literature regarding the exact mechanism responsible for the development of bisphosphonate-induced osteonecrosis of the jaw. Furthermore, it is observed that the treatment of this condition still lacks standardized and universally accepted protocols, which reinforces the need for further studies on the topic.