Real-World Data Related to Non-Metastatic Breast Cancer in Young Women: Experience of a Single Institution

• DOI: 10.22533/at.ed.02619030430

• Palavras-chave: Atena

• Keywords: Breast Neoplasms; Young Adult; Health Services Research.

• Abstract:

  Breast cancer is the leading cause

  of cancer-related deaths in women aged 20

  to 59 years old. Young women usually have

  more aggressive tumors and more advanced

  disease with larger size and axillary nodal

  involvement. There are few studies assessing

  the characteristics of breast cancer in very young

  women. Method: We performed a retrospective

  analysis to evaluate the epidemiological and

  clinical profile of non-metastatic breast cancer

  patients with 30 years of age and younger

  treated between 1993 and 2011 at the Brazilian

  National Cancer Institute (INCA). Results:

  From the 196 patients evaluated, 181 patients

  (90%) had ductal carcinoma, 79 (40%) highgrade

  tumors, and 102 (52%) were HR positive.

  117 patients (60%) were classified as stage III

  at diagnosis. The median age was 29 y (range:

  17-30y). Of 185 patients who underwent

  surgery, 156 (84.3%) had total mastectomy, and

  171 (92%) had axillary node dissection. 119

  patients received neoadjuvant chemotherapy,

  and 14 patients (9.3%) underwent neoadjuvant

  radiotherapy. After a median follow-up of 81.5

  months, there were 109 relapses (55%) and

  81 deaths (41%). Median RFS and OS was

  49.5 months and 134 months, respectively.

  Positive node involvement and neoadjuvant

  chemotherapy were associated with shorter

  RFS and OS. Conclusion: Breast cancer is not

  frequent in young patients, especially under 31

  years of age. We found more locally advanced

  disease and worse prognostic pathological

  characteristics. Despite the aggressive

  treatment, our patients had worse outcomes

  than reported by other authors.

• Número de páginas: 15