PRIMARY NEUROENDOCRINE NEOPLASM OF THE ESOPHAGUS – REPORT OF 14 CASES FROM A SINGLE INSTITUTE AND REVIEW OF THE LITERATURE

• DOI: 10.22533/at.ed.14619200616

• Palavras-chave: Tumores de esôfago, carcinoide, tumor neuroendócrino

• Keywords: Neuroendocrine tumors, Esophageal neoplasms, Small cell carcinoma, Carcinoid tumor

• Abstract:

  Most prevalent

  esophageal neoplasm is squamous cell

  carcinoma and adenocarcinoma. Other tumors

  are uncommon and poorly studied. Primary

  neuroendocrine esophageal neoplasm is a rare

  carcinoma and most of its therapy management

  is based on lung neuroendocrine studies.

  Neuroendocrine tumors can be clustered in

  the following subtypes: high grade (small cell

  carcinoma or large cell carcinoma) and low

  grade (carcinoids). Objectives: The present

  study aims to assess clinical and pathological

  neuroendocrine esophageal tumors in a single

  oncologic center. Methods: A retrospective

  analysis of patients and review of the literatures

  was performed. Fourteen patients were identified

  as neuroendocrine tumors, 11 male and 3 female

  patients. Mean age was 67.3 years old. Ten

  patients were classified as small cell, 3 as large

  cell and 1 as carcinoid. Four patients presented

  squamous cell carcinoma simultaneously and

  1 also presented adenocarcinoma. Main sites

  of metastasis were liver, peritoneum, lung

  and bones. Most patients died before 2 years

  of follow-up. Patient with longer survival died

  at 35 months after diagnosis. Conclusions:

  Neuroendocrine esophageal tumors are rare;

  affect mainly men in their sixties or seventies.

  High grade tumors can be mixed to other

  subtypes neoplasms, such as adenocarcinoma

  and squamous cell carcinoma. Most of these

  patients have poor overall survival rates

• Número de páginas: 15