POTENCIAL TROMBOLÍTICO DE ENZIMAS MICROBIANAS: UMA ABORDAGEM PROMISSORA PARA O TRATAMENTO DE TROMBOSE
POTENCIAL TROMBOLÍTICO DE ENZIMAS MICROBIANAS: UMA ABORDAGEM PROMISSORA PARA O TRATAMENTO DE TROMBOSE
-
DOI: https://doi.org/10.22533/at.ed.8222427034
-
Palavras-chave: fermentação, enzimas microbianas, doenças cardiovasculares
-
Keywords: fermentation, microbial enzymes, cardiovascular diseases
-
Abstract: Cardiovascular diseases associated with thrombosis are one of the main causes of death in the whole world. Urokinase, streptokinase, and tissue plasminogen activator are the major thrombolytic agents used to treat thrombosis. These agents have been widely used in the medical clinic. However, factors such as short half-lives, high production costs and hemorrhagic complications have driven the search for safer and more economically viable compounds for the treatment of cardiovascular diseases. In this way, the fibrinolytic and fibrinogenolytic enzymes secreted by fungi promising alternatives, since they promote the direct degradation of the thrombi and does not induce side effects, besides having a low cost of production. In this chapter, we will explore the potential of fibrinolytic and fibrinogenolytic enzymes secreted by microorganisms as promising alternatives in the treatment of cardiovascular diseases associated with thrombosis, highlighting their ability for direct thrombus degradation, absence of side effects, and reduced production costs.
- Cristiani Baldo da Rocha
- Lillian Maria Baggio
- Edna Suzana António Jinga
- Hyan Gabriel Barbosa Da Costa
- Antonio Carlos da Silva Vieira
- Nubia Natalia Lopes Cardoso
