POTENCIAL TERAPÊUTICO DE LIPOPEPTÍDEOS MICROBIANOS CONTRA INFECÇÕES BACTERIANAS MULTIRRESISTENTES

• DOI: https://doi.org/10.22533/at.ed.9872421063

• Palavras-chave: Fermentação, biossurfactantes, surfactina, infecções bacterianas.

• Keywords: Fermentation, biosurfactants, surfactin, bacterial infections.

• Abstract: Bacterial infectious diseases represent a global threat, contributing significantly to morbidity and mortality. Annually, these diseases are responsible for more than 700,000 deaths worldwide, mainly due to microbial resistance to the available antibiotics on the market. Faced with this challenge, the research of new antimicrobial molecules, such as lipopeptides, has stood out. Produced by bacteria of the Bacillus genus, lipopeptides are biosurfactants with diverse properties and act as potent antimicrobial agents against various pathogens of importance in the healthcare field. Despite the low yield in production, efforts are being directed towards identifying new producing strains and optimizing the production process, aiming at the development of new products to combat multi-drug resistant bacterial infections. This chapter focuses on the main classes of lipopeptides with an emphasis on their antimicrobial action against medical important bacteria.