POTENCIAL ANTIPROLIFERATIVO IN VITRO EM LINHAGENS CELULARES TUMORAIS HUMANAS DO EXTRATO DA PLANTA Coccocypselum lanceolatum (RUBIACEAE)

• DOI: https://doi.org/10.22533/at.ed.7562427124

• Palavras-chave: Coccocypselum lanceolatum, Rubiaceae, Células tumorais, Antiproliferativo.

• Keywords: Coccocypselum lanceolatum, Rubiaceae, Tumor cell lines, Antiproliferative.

• Abstract: ABSTRACT: Coccocypselum lanceolatum (Ruiz & Pav.) Pers., popular known as “cauabori” and “azulzinha-do-bosque” is considered a medicinal herb used in the treatment of pain and inflammation, in addition to being used with antivenom properties and in the food sector. This study evaluated the antiproliferative activity of extract from C. lanceolatum on nine human tumor cell lines and one non- tumoral human cell line (HaCaT), using doxorubicin as positive control. The extract exhibited antiproliferative effect for eight strains tested, with TGI 4.05 μg mL–1 to 92.46 μg mL–1 . The results showed a potente selective cytostatic antiproliferative effect at a concentration of 0.25 μg mL–1 for the UACC-62 strain and at a concentration of 2.5 μg mL–1 for the UACC-62 and OVCAR-3 strains with TGI 4.05 μg mL–1 and 7.07 μg mL–1 , as well as high selectivity index SI 10.20 and 5.84, respectively. The UACC-62 and OVCAR-3 strains still demonstred a selective cytocidal effect reaching 100%. Additionally, the extract reveled a moderate cytostatic effect against the MCF-7 and PC-3 strains. C. lanceolatum showed promising anticancer activity, however, new studies must be conducted in an attempt to isolate and identify bioactive chemical constituents. Additional studies in the pharmacology are also relevant, mainly in elucidating the mechanism of action and toxicity in vivo experiments.