POLIMORFISMOS DOS GENES LDLR E ZPR1 E ASSOCIAÇÃO DE DOENÇAS CARDIOVASCULARES EM POLICIAIS MILITARES
POLIMORFISMOS DOS GENES LDLR E ZPR1 E ASSOCIAÇÃO DE DOENÇAS CARDIOVASCULARES EM POLICIAIS MILITARES
DOI: https://doi.org/10.22533/at.ed.7492427123
Palavras-chave: Aterosclerose. Gene LDLR. Gene ZPR1. Policial militar. Polimorfismo genético.
Keywords: Atherosclerosis. LDLR gene. ZPR1 gene. Military police officer. Genetic polymorphism
Abstract: Police officers are categorized as one of the classes of public servants that are most exposed to the development of chronic non-communicable diseases, with chronic vascular diseases being the most prevalent, mainly atherosclerosis. In an intense way, family genetic inheritance is the most important independent risk condition in the development of atherosclerosis. Genetic polymorphisms are related to the development of numerous diseases, since the genetic factor is strongly linked to this process, and this influence is also present in atherosclerosis. More than 400 genes are described in the literature as strong participants in the origin of the atherogenic process, with relevance to the genes CYP, GSTs, ApoE, eNOS, ApoB, LDLR, Apo A-I, Apo C-III, hepatic lipase, ester transfer protein cholesterol (CETP) and lipoprotein lipase (LPL), which have been the subject of studies to better understand their role in the development of pathological changes. In this sense, this chapter addresses the influence of the LDLR (LDL receptor) genes and the ZPR1 gene, which appear to be associated with the risk of atherosclerosis, especially in military police officers
- Fábio Castro Ferreira
- Murilo Barros-Silveira
- Jhonathan Gonçalves da Rocha
- Josué Moura Telles
- Lucas dos Santos Freitas
- Bruno Henrique da Silva
- Douglas Ferreira Silva
- João Pedro Souza Martins
- Luiza Cristina de Moraes e Silva
- Jorge Armando Pereira de Godoy
- Ellen de Sousa Monteiro
- Lais Silva dos Santos
- Iasmim Ribeiro da Costa
- Frank Sousa Castro
- Sérgio Henrique Nascente Costa
- Lídia Andreu Guillo