PESQUISA EM SAÚDE BUCAL: O CONSUMO DE DIETAS RICAS EM GORDURA E AS DOENÇAS ORAIS OSTEOLÍTICAS
PESQUISA EM SAÚDE BUCAL: O CONSUMO DE DIETAS RICAS EM GORDURA E AS DOENÇAS ORAIS OSTEOLÍTICAS
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DOI: https://doi.org/10.22533/at.ed.8062420063
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Palavras-chave: gorduras na dieta; dislipidemia; periodontite; lesão periapical; citocinas; reabsorção óssea
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Keywords: dietary fats; dyslipidemia; periapical lesion; cytokines; bone resorption
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Abstract: The connection between high-fat diets and immunomediated oral diseases, such as those involving periodontal tissues supporting dental elements, has been the subject of recent dental research. In summary, contemporary evidence suggests that excessive fat intake through diet can trigger systemic inflammatory responses that affect oral health, considering the health-disease process, as well as associated obesity and metabolic syndrome. Chronic inflammation associated with a high-fat diet affects the local immune response in the oral cavity, predisposing individuals to exacerbated inflammation and bone resorption in the oral cavity. Cellular and molecular interactions often result in elevated levels of pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6, along with increased expression of bone resorption mediators like RANKL. However, while the state of the art is advanced regarding periodontitis, there are still gaps regarding apical periodontitis. This chapter details the interactions related to the pathogenesis of osteolytic oral diseases (periodontitis and apical periodontitis) and the consumption of high-fat diets, pointing out advances and perspectives that still need to be explored in further research.
- Ricardo Barbosa Lima
- Ana Paula Gomes e Moura
- Aluísio Eustáquio de Freitas Miranda Filho
- Lisa Danielly Curcino Araujo
- Alana Cândido Paulo
- Marília Pacífico Lucisano
- Paulo Nelson Filho
- Léa Assed Bezerra da Silva
- Raquel Assed Bezerra da Silva