PERSPECTIVAS DA UTILIZAÇAO DA TÉCNICA CRISPR/CAS9 NA TERAPIA GÊNICA
PERSPECTIVAS DA UTILIZAÇAO DA TÉCNICA CRISPR/CAS9 NA TERAPIA GÊNICA
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DOI: https://doi.org/10.22533/at.ed.48824050214
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Palavras-chave: CRISPR/Cas9, Engenharia Genética e Terapia Gênica
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Keywords: CRISPR/ Cas9, Genetic Engineering and Gene Therapy
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Abstract: Introduction: The discovery of a guide RNA associated with a Cas protein has become an innovative tool in gene editing, and the CRISPR/ Ca9 technology used in gene therapy can provide not only DNA correction but also introduce a new feature , preventing hereditary diseases from being transmitted to descendants. Objective: The objective is to identify the use of the cripCas9 technique with gene therapy in the treatment of different pathologies. Materials and Methods: Work was developed through a narrative review. For the survey of articles in the literature, the following databases were used: SCIELO, PubMed, MEDLINE and Google Scholar. With exclusion and exclusion criteria. Results and Discussion: Description of the mechanism of action of CRISPR / Cas9 and its application in medicine. Conclusion - In gene therapy, drug treatment has a very high cost, and since CRISPR / Cas9 obtained good results in the face of some genetic diseases, its use in the treatment of diseases arising from alterations in DNA is promising, assuming that the probabilities of benefits greater than those of harm.
- Hingridh Leal Rodrigues
- Benedito Rodrigues da Silva Neto
