PAPEL DOS MicroRNAs NA REGULAÇÃO DE GENES ASSOCIADOS A DOENÇAS NEURODEGENERATIVAS: IMPLICAÇÕES E MECANISMOS MOLECULARES
PAPEL DOS MicroRNAs NA REGULAÇÃO DE GENES ASSOCIADOS A DOENÇAS NEURODEGENERATIVAS: IMPLICAÇÕES E MECANISMOS MOLECULARES
DOI: https://doi.org/10.22533/at.ed.44925210312
Palavras-chave: MicroRNAs, regulação gênica, doenças neurodegenerativas, biomarcadores.
Keywords: microRNAs, gene regulation, neurodegenerative diseases, biomarkers.
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that play a critical role in post-transcriptional gene regulation. They are involved in various cellular processes and have a significant impact on neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis. Altered miRNA expression can influence the activity of key genes associated with neuroinflammation, cell death, autophagy, and other pathways relevant to these conditions. These features highlight miRNAs as promising biomarkers for early diagnosis and potential therapeutic targets, contributing to the development of more effective strategies against neurodegenerative diseases.
- Fernanda Paloma Duarte Trierweiler
- Samuel Everson Alves Moraes
- Letícia Santana De Jesus
- Rafael de Carvalho Sacramento
- Amanda Carol Costa de Melo
- Brunna Pâmella Dos Anjos Nascimento
- José Isac Guedes da Silva
- Carol Reis de Souza
- Yuri Leite Da Silva
- João Matheus Pereira Falcão Nunes
- Bruno Miranda Santos de Oliveira
