PANCREATITE AGUDA EM CRIANÇAS: RARO?
PANCREATITE AGUDA EM CRIANÇAS: RARO?
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DOI: 10.22533/at.ed.94523181218
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Palavras-chave: Pancreatite aguda, Crianças, Etiologia, Revisão
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Keywords: Acute pancreatitis, Children, Etiology, Review
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Abstract: ABSTRACT BACKGROUND: Acute pancreatitis is a necroinflammatory tissue reaction to functional and/or structural damage to acinar cells and rarely necrosis of ductal cells, caused by non-infectious factors. In acute pancreatitis there is extensive release of pancreatic enzymes along with their intrapancreatic activation, and may cause peripancreatic necrosis. In children, this disease has a few studies. Thus, the aim of this study is to know the profile of acute pancreatitis in children. METHODS: A horizontal systematic review of acute pancreatitis in children was performed using the PRISMA method in the Pubmed database. Keywords: "acute pancreatitis AND [children OR child OR childhood]". Also added articles related to the topic/"cited by" and "similar articles" sessions. RESULTS: From the initial 43, 12 articles were selected, being the United States the country with the largest number of published papers. White ethnicity had the highest number of cases and the ratio of women ranged between 32.4% and 59.5%; and of men, between 40.5% and 67.5%, not being able to say that there is a gender prevalence. The median age of the patients had an interval from 5 to 11.6 years. The main etiologies pointed out by the studies were: biliary tract diseases, idiopathic etiology, medication, and systemic disease. DISCUSSION: Surprisingly we found few articles, making it difficult to analyze the subject, since case reports and retrospective studies on acute pancreatitis in children were found without standardization as to age range and etiology, with great variations as to which etiologies were being considered and the minimum and maximum ages. Therefore, considering the available information, it can be concluded that biliary tract diseases constitute the main etiology of acute pancreatitis in children, which coincides with literature on etiology of acute pancreatitis in adults. CONCLUSION: The lack of consensus on diagnostic parameters and neglect of gastric symptoms in children may have generated underdiagnosis of acute pancreatitis cases. Added to this is the underreporting of these cases, which has led to a little literature available on acute pancreatitis in children and perhaps a false idea of a rare disease. Thus, it's important to be more watchful of gastrointestinal symptoms in children and to make a better diagnostic pattern of this disease.
- Karina de Oliveira Pinheiro
- Roberta Rezende Lara
- Beatriz Tezzon
- Julye Tainah de Fátima Seminari Pagani
- Ethel Zimberg Chehter