O IMPACTO DAS NITROSAMINAS NO CENÁRIO FARMACÊUTICO: CONTAMINAÇÃO EM MEDICAMENTOS E A AÇÃO DA VIGILÂCIA SANITÁRIA
O IMPACTO DAS NITROSAMINAS NO CENÁRIO FARMACÊUTICO: CONTAMINAÇÃO EM MEDICAMENTOS E A AÇÃO DA VIGILÂCIA SANITÁRIA
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DOI: https://doi.org/10.22533/at.ed.35324080810
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Palavras-chave: Nitrosaminas. Agência Nacional de Vigilância Sanitária. Impureza.
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Keywords: Nitrosamines. National Health Surveillance Agency. Impurity.
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Abstract: The National Health Surveillance Agency (ANVISA), through RDC nº 53, of December 4, 2015, and RDC nº 677, April 28, 2022, imposed limits on the amount of impurities and rules for possible collections of food, drinks and medicines. Therefore, this course completion work aims to present medicines that have already been contaminated by nitrosamines, the actions of health surveillance and the possible consequences for the final consumer. Nitrosamines are carcinogenic chemical compounds that have the chemical structure R2N-N=O and are formed from a nitroso group and an amine, in addition to having around 28 different forms of structure. Of these types of impurities, it is true that they are carcinogenic and possibly responsible for the mutation of DNA genes, mainly causing stomach and intestinal cancer. The records of nitrosamine contamination found and cited in this article from 2019 to 2022.
- Samara Oliveira Pinto
- Layane de Sousa Lima
- Hellen Dinne de Souza do Nascimento