Miostatina e sua relação com a sarcopenia

• DOI: https://doi.org/10.22533/at.ed.00424170711

• Palavras-chave: Exercício físico; massa muscular; neurodegeneração.

• Keywords: Physical exercise; muscle mass; neurodegeneration.

• Abstract: The world's population is aging rapidly, and it is estimated that by 2050 the elderly population will reach approximately 2 billion people. However, aging brings both cognitive and physical decline, with sarcopenia being one of the main emerging diseases affecting the physical capacity of the elderly. Sarcopenia is a condition characterized by the progressive loss of skeletal muscle mass, strength, and function, limiting individuals' independence and increasing the risk of falls and injuries. Regular physical exercise, especially resistance training, is essential for both the prevention and treatment of sarcopenia, promoting muscle mass gain and function. Understanding the molecular mechanisms involved in sarcopenia is crucial for better treatment outcomes, such as with resistance training. Evidence suggests that myostatin plays a role in various physiological and pathological processes, including its relationship with aging and muscle condition. Myostatin concentration is inversely related to muscle mass levels. Resistance exercise combined with myostatin inhibitors shows potential for preventing and treating sarcopenia, as well as promoting muscle mass gain in neurodegenerative conditions. However, the mechanisms by which physical exercise may reduce myostatin levels remain unknown.