MINERAÇÃO DE GENOMAS A PARTIR DE SEQUENCIAMENTO DE METAGENOMAS DE AMOSTRAS DA AMAZÔNIA: UMA BUSCA POR PROTEASES
MINERAÇÃO DE GENOMAS A PARTIR DE SEQUENCIAMENTO DE METAGENOMAS DE AMOSTRAS DA AMAZÔNIA: UMA BUSCA POR PROTEASES
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DOI: https://doi.org/10.22533/at.ed.1642407032
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Palavras-chave: bioprospecção, enzimas, peptidase, potencial biotecnológico
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Keywords: bioprospection, enzymes, peptidase, biotechnological potential
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Abstract: The present study investigated genomes assembled from metagenome sequencing of Amazonian samples in search of potential new proteases and peptidases. Utilizing techniques for mining genomes/metagenomes deposited in databases, we identified 23 potential proteases/peptidases with varying sizes classified as hypothetical proteins. One particular protease exhibited homology with the Peptidase S1 superfamily, standing out with a 60% similarity to known enzymes considering chemically similar amino acids. Comparative analysis revealed the presence of a trypsin-like peptidase domain. This work underscores the significance of the Amazon as a promising source of enzymes for biotechnological applications. Future research endeavors should focus on synthesizing and experimentally evaluating these enzymes, especially those associated with hypothetical proteins, to confirm their activities and explore their potential use across diverse industrial sectors. This study highlights not only the unique biotechnological diversity of the Amazon but also emphasizes the need for sustainable practices and collaboration (directly or indirectly) among researchers to maximize the understanding and utilization of these resources
- Eric de Lima Silva Marques
- Adriana Barros de Cerqueira e Silva
- Mariana Barros de Cerqueira e Silva