Microencapsulated and nanoencapsulated flavonoids against glioblastoma cells

• DOI: 10.22533/at.ed.2832328126

• Palavras-chave: Flavonoides, microcápsulas, nanocápsulas, análise de estado sólido por RMN, gliobastoma.

• Keywords: Flavonoids, microcapsules, nanocapsules, NMR Solid analysis, glioblastoma.

• Abstract: Abstract: The applications of microcapsules include the controlled release of drugs, protection against rust or protection of substances against interactions with the environment. Biodegradable microcapsules are typically used to increase the therapeutic value of water-soluble or –insoluble medicinal drugs, increasing bioavailability, solubility and retention time.  Flavonoids are a class of metabolites with many biological properties. In the present study we prepared microcapsules and nanocapsules  of the flavonoids apigenin, 7-apiosyl scutellarein and quercetin to be tested against different glioblastoma (GBM) cell lines.  Nanocapsules of 7-apiosyl-scutellarein reduced the viability of U87 and GBM 95 cell lines. Microcapsules of apigenin and quercetin reduced cell viability and number of cells in culture in all GBM cell lines tested. Flavonoids and microcapsules were not cytotoxic to astrocytes. This is the first report of 7-apyosil-scutellarein nanocapsules and their assays against gliomas.