METABOLISMO DA VITAMINA D E POLIMORFISMOS DO GENE RECEPTOR DA VITAMINA D

• DOI: https://doi.org/10.22533/at.ed.9832516095

• Palavras-chave: Vitamina D; Polimorfismos; Gene VDR.

• Keywords: Vitamin D; Polymorphisms, VDR Gene.

• Abstract: Vitamin D is a lipophilic nutrient of extreme importance for calcium and iron homeostasis, bone health, immunity, oxidative stress control, and response to cancer treatment. The main forms of vitamin D are D3, present in animal foods, and D2, derived from plants and fungi. Both are inactive and require hepatic and renal hydroxylation to form calcitrol, which interacts with the vitamin D receptor (VDR), modulating more than 900 genes and important physiological processes. Polymorphisms such as ApaI, BsmI, FokI, and TaqI can alter VDR function, impacting its translation, structure, and biological activity. These variations can attenuate cellular sensitivity to vitamin D and interfere with gene regulation, affecting calcium, immunity, and the risk of chronic diseases. Assessing these polymorphisms allows for personalized supplementation, identification of risk biomarkers, and guidance for preventive and therapeutic strategies.