MARCADORES GENÉTICOS E POLIMORFISMOS ENVOLVIDOS NO METABOLISMO DA VITAMINA D – UMA REVISÃO CONCEITUAL

• DOI: 10.22533/at.ed.94523181222

• Palavras-chave: vitamina D, Gene VDR, CYP27B1, CYP24A1

• Keywords: vitamin D, VDR gene, CYP27B1, CYP24A1

• Abstract: Genetic polymorphisms related to vitamin D metabolism can affect the production, transport, and activity of this vitamin, influencing individual response to its intake. Additionally, the synthesis of vitamin D in the skin in response to sunlight exposure can be influenced by genetic factors. Vitamin D deficiency has been associated with various chronic diseases, such as cardiovascular diseases, diabetes, cancer, and autoimmune diseases. Genetic variants, including polymorphisms in the VDR, CYP27B1, and CYP24A1 genes, can influence the association between vitamin D and these diseases, affecting the activity of vitamin D and the risk of developing them. The objective of this study is to conduct a literature review to investigate the metabolic pathways of vitamin D and the polymorphisms that may occur, altering this physiological metabolic pathway. The results found were extensive, providing data on the prevalence of polymorphisms and a higher deficiency of the nutrient, which may possibly lead to the increased occurrence of various non-communicable chronic diseases. Therefore, the conclusion is that screening for vitamin D in the general population, including those in more tropical countries, is of utmost importance because sunlight exposure is not the sole decisive marker for maintaining adequate circulating levels of vitamin D.