MANEJO DA ENXAQUECA REFRATÁRIA: UMA ANÁLISE PROFUNDA DOS ANTICORPOS MONOCLONAIS ANTI-CGRP E DA MODULAÇÃO MULTIMODAL DO ESTILO DE VIDA
MANEJO DA ENXAQUECA REFRATÁRIA: UMA ANÁLISE PROFUNDA DOS ANTICORPOS MONOCLONAIS ANTI-CGRP E DA MODULAÇÃO MULTIMODAL DO ESTILO DE VIDA
-
DOI: https://doi.org/10.22533/at.ed.486162606014
-
Palavras-chave: Cefaleia Primária. CGRP. Anticorpos Monoclonais. Medicina de Precisão. Neuroinflamação.
-
Keywords: Primary Headache. CGRP. Monoclonal Antibodies. Precision Medicine. Neuroinflammation.
-
Abstract: Migraine is a highly prevalent chronic neurovascular pathology, recognized by the World Health Organization as one of the most disabling conditions worldwide. Clinical management becomes particularly complex in cases of refractory migraine, characterized by systematic therapeutic failure to conventional prophylactic classes. This chapter profoundly reviews pathophysiological advances focused on the Calcitonin Gene-Related Peptide (CGRP) and the subsequent therapeutic revolution of monoclonal antibodies. Beyond pharmacological innovation, the need for an integrative multimodal approach is analyzed, encompassing chronobiology, nutrition, and stress modulation. The objective is to provide a comprehensive guide for modern clinical practice, aiming for symptom remission in patients with a high disease burden and severe therapeutic resistance.
- Jessica Estevam de Sousa