INVESTIGAÇÃO DE PRODUTOS NATURAIS BIOATIVOS COMO POTENCIAIS AGENTES CONTRA Aedes aegypti
INVESTIGAÇÃO DE PRODUTOS NATURAIS BIOATIVOS COMO POTENCIAIS AGENTES CONTRA Aedes aegypti
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DOI: https://doi.org/10.22533/at.ed.9781125180363
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Palavras-chave: Aedes aegypti, Plantas medicinais, Dengue, Bioativos Naturais
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Keywords: Aedes aegypti, medicinal plants, dengue, natural bioactives
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Abstract: ABSTRACT: Dengue is the most prevalent arbovirus disease in the world, present in more than 100 countries. Its main vector, the Aedes aegypti mosquito, constitutes a serious public health problem. Although Brazil has vaccines, the number of cases remains high, mainly due to the simultaneous circulation of different serotypes of the virus. Therefore, the use of plants with insecticidal properties emerges as an effective and ecologically sustainable alternative for vector control. This study aimed to investigate natural compounds with insecticidal potential against Aedes aegypti. For this, a literature review was conducted in the PubMed, ScienceDirect, and Scopus databases, encompassing articles published between January 2019 and January 2024. The descriptors “Aedes aegypti” and “Natural products” were used. Original studies presenting experimental data on the insecticidal activity of natural substances against the vector, or in silico studies, were included, considering the methodological quality and scientific relevance of the selected works. The initial search resulted in 165 articles, of which 16 were chosen to compose the review. The chemical structures of the identified compounds were obtained from the PubChem database in 2D format. Thirty-two plant species belonging to 16 botanical families were identified. The predominant form of extraction was through essential oils, which stand out for their low toxicity to animals and structural diversity. These oils act as insecticides through neurotoxic effects, interfering with receptors such as gamma-aminobutyric acid (GABA). Most of the identified compounds are terpenes, while the others include aldehydes, alkaloids, phenolic compounds, ketones, and others. The results highlight the potential of natural compounds, especially terpene-rich essential oils, as promising insecticidal agents in the fight against A. aegypti. Their efficacy, combined with low toxicity and structural diversity, makes these substances a sustainable and viable alternative to conventional vector control approaches.
- Welina Carvalho Silva
- Wallyson André dos Santos Bezerra
