Interações sinérgicas entre substâncias bioativas

• DOI: 10.22533/at.ed.6002317108

• Palavras-chave: Interações Sinérgicas; Substâncias Bioativas; Sinergia.

• Keywords: Synergistic Interactions; Bioactive Substances; Synergy.

• Abstract: Introduction: Sympathy for synergistic actions between bioactive substances has increased in recent years due to recent paradigm shifts. The search for selective molecules with a single mechanism of action, the behavior most frequently sought in research on new drug candidates, has been giving way to the development of multiple therapies, with the aim of acting simultaneously and concomitantly on various therapeutic targets. Objective: Review the literature to verify synergistic interactions between bioactive substances and their importance. Methods: This study constitutes a systematic review, classified as exploratory and descriptive. The elaboration of the research was bibliographical research in electronic databases on methods associated with RSL (Systematic Literature Review) and SMARTER applications (Simple Multi-Attribute Rating Technique using Exploiting Rankings). Results: A comprehensive systematic literature search yielded a total of 772 articles referring to synergy between bioactive substances. Of these, 36 articles became eligible to compose this systematic review. Conclusion: The study concluded that most efforts devoted to natural product knowledge are typically devoted to reducing complexity and identifying unique active components for drug development.