Infecção humana por exposição acidental a vacinas antibrucélicas - cepas B19 e RB51: uma Revisão Sistemática da Literatura

• DOI: https://doi.org/10.22533/at.ed.9252404068

• Palavras-chave: Brucelose; vacinas B19 e RB51; exposição acidental, One Health

• Keywords: Brucellosis; vaccines S19 and RB51; accidental exposure, One Health

• Abstract: Introduction: brucellosis is a communicable disease of great importance: both for its socioeconomic and public health aspects, since it significantly affects the international trade of animals and their products. Among the official measures for the disease’s control is the compulsory vaccination of bovine females through live attenuated bacterins – S19 and RB51 strains. Objective: The aim of the present study was to perform a qualitative synthesis through a systematic literature review on the occurrence of infection of humans by anti-Brucella vaccine - S19 and RB51 strains, as these are the most common and licensed immunogens for application in cattle in most countries that adopt control measures against bovine brucellosis. Material and Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) methodology was used for the primary research of scientific literature in these five electronic databases: Pubmed, Science Direct, Scopus, Web of Science and Scielo. Then, it was complemented by a process of screening and selection of articles and, finally, data extraction and analysis. Results: published studies are rare; The majority (06/10) of the selected texts are of the "case report" modality. We also found a text (01/10) addressing "case series report" and three other articles (03/10) of the cross- sectional study type. These publications come from countries of 04 continents: America (Argentina, Brazil and the United States); Asia (Turkey) and Africa (Sudan). Discussion: Vaccination is one of the most important tools to be used in the control phase of bovine brucellosis. However, its use should be conditioned to the epidemiological survey of the disease in the herd to be immunized, mainly due to the possibility of the human infection occurrence - directly or indirectly - by the vaccine strains currently available.