INCIDÊNCIA E IMPACTOS DA NEUTROPENIA FEBRIL EM PACIENTES COM TUMORES HEMATOLÓGICOS HOSPITALIZADOS
INCIDÊNCIA E IMPACTOS DA NEUTROPENIA FEBRIL EM PACIENTES COM TUMORES HEMATOLÓGICOS HOSPITALIZADOS
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DOI: https://doi.org/10.22533/at.ed.3522410042
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Palavras-chave: Neutropenia Febril; Tumores hematológicos; Toxicidade; Infecção; Hematologia.
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Keywords: Febrile Neutropenic; Hematologic malignancies; Toxicity; Infection, Hematology.
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Abstract: Febrile Neutropenia is a serious consequence that affects patients with hematological tumors, patients with this recent diagnosis, undergoing myelotoxic treatments, with chemotherapy being the most common. The toxicity of the dose and the type of treatment proposed predisposes these patients to diseases such as Febrile Neutropenia, when untreated, this pathology often progresses to sepsis and even death. This is a descriptive and retrospective study carried out in a cancer reference hospital in the Federal District. The study sample was made up of patients with hematological tumors hospitalized between January and July 2020, with the same patient being evaluated repeatedly. Data collection was carried out through electronic medical records using a previously structured questionnaire to evaluate qualitative and quantitative variables. 234 were evaluated, of which 53 patients progressed to Febrile Neutropenia. The most common hematological diagnosis was Acute Lymphoblastic Leukemia -ALL- (37%), followed by Non-Hodgkin Lymphoma - NHL- (35%). The most common chemotherapy protocols were: HyperCVAD (40%), followed by R-CHOP (9%), directly coinciding with the most prevalent diagnoses (ALL and NHL). Regarding chemotherapy, 24.52% of patients with NF showed a delay in the next Qt cycle and 5.6% showed a dose reduction, in addition to 36% (n=19) of patients showing an increase between 5–10 days of hospitalization As for infection rates, 23% (n=12) of patients with NF progressed to sepsis, with the main focus being the Abdominal (68%). Regarding the stage of hospitalization of patients with NF who presented sepsis, 41% died. Note that untreated NF can lead to clinical worsening, development of sepsis, increased hospital stay and even death.
- Davi da Silva Nascimento
- Jéssica dos Santos Guedes
- Débora Cristina Aleixo Lara
- Kamila Rocha Fernandes Lima
- Karisia Karen Ricarte Lô
- Isabella Mayara Cleide Diana Mariana Nepomuceno de Souza