IMUNOTERAPIA NO CÂNCER GÁSTRICO: AVANÇOS CLÍNICOS, DESAFIOS E PERSPECTIVAS FUTURAS
IMUNOTERAPIA NO CÂNCER GÁSTRICO: AVANÇOS CLÍNICOS, DESAFIOS E PERSPECTIVAS FUTURAS
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DOI: https://doi.org/10.22533/at.ed.156132516044
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Palavras-chave: Imunoterapia; câncer gástrico; avanço.
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Keywords: Immunotherapy; gastric cancer; advances.
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Abstract: Immunotherapy has emerged as an innovative approach for gastric cancer treatment, offering new therapeutic strategies for patients with advanced disease. The use of PD-1/PD-L1 inhibitors has demonstrated significant benefits, particularly in tumors with high PD-L1 expression. Additionally, combining immunotherapy with chemotherapy, tyrosine kinase inhibitors, and therapeutic vaccines has shown potential in improving clinical outcomes. However, challenges such as treatment resistance, toxicity, and tumor heterogeneity limit its effectiveness. The identification of predictive biomarkers has been essential in optimizing patient selection. Future studies should explore novel strategies, including immunomodulators and artificial intelligence, to enhance treatment personalization. While immunotherapy represents a significant breakthrough in gastric cancer, further research is needed to overcome its current limitations and improve both its efficacy and safety.
- Carolina Pimentel Fogaça de Souza
- Matheus de Castro Fernandes Andrade
- Débora Lucy de Souza Bastos Antonio
- Juliana Tavares de Araújo
- Matheus de Souza Joaquim
- Beatriz Almeida Assed Kiki
- Ramon Fraga de Souza Lima
- Maisa Cristina Ramos Batista