IMUNOLOGIA DA PERIODONTITE: UMA ANÁLISE DOS MECANISMOS IMUNOLÓGICOS ENVOLVIDOS NA PATOGÊNESE DA DOENÇA PERIODONTAL
IMUNOLOGIA DA PERIODONTITE: UMA ANÁLISE DOS MECANISMOS IMUNOLÓGICOS ENVOLVIDOS NA PATOGÊNESE DA DOENÇA PERIODONTAL
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DOI: https://doi.org/10.22533/at.ed.8022401042
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Palavras-chave: Resposta imunológica; Microrganismos Periodontopatogênicos; Desequilíbrio imunológico
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Keywords: Immune response; Periodontopathogenic microorganisms; Immunological imbalance
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Abstract: Periodontitis is a chronic inflammatory disease affecting the supportive tissues of the teeth, leading to the degradation of the periodontal ligament and alveolar bone loss. Immunological mechanisms play a crucial role in the pathogenesis of periodontitis, involving an exacerbated inflammatory response to periodontopathogenic microorganisms. The presence of bacterial biofilm triggers the activation of immune cells, such as neutrophils and macrophages, releasing pro-inflammatory mediators. The adaptive immune response is also engaged, with T and B lymphocytes contributing to the inflammatory cascade. However, an imbalance in these mechanisms can lead to an inadequate immune response, resulting in progressive tissue damage. Understanding these mechanisms is essential for the development of targeted therapeutic approaches aimed at modulating the immune response and controlling the progression of periodontitis.
- Jordania Marques de Oliveira Freire
- Livya Maria Vasconcelos Lima Sousa
- Ívina Alcântara Rodrigues
- Beatriz Silva de Sousa
- Raissa Linhares Ribeiro de Menezes
- Ana Luiza Silva Nascimento
- Matheus Martins de Oliveira
- Idinez Yury Aguiar Costa
