HEMOGLOBINA GLICADA COMO BIOMARCADOR PRECOCE PARA A DOENÇA DE ALZHEIMER: UMA ABORDAGEM NEUROENDÓCRINA INTEGRADA
HEMOGLOBINA GLICADA COMO BIOMARCADOR PRECOCE PARA A DOENÇA DE ALZHEIMER: UMA ABORDAGEM NEUROENDÓCRINA INTEGRADA
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DOI: https://doi.org/10.22533/at.ed.9832516092
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Palavras-chave: Biomarcador, Alzheimer, paciente.
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Keywords: Biomarker, Alzheimer's, patient
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Abstract: This article discusses the use of glycated hemoglobin (HbA1c) as an early biomarker for Alzheimer's disease (AD) risk. Through a critical review of recent literature, strong correlations were identified between poor glycemic control and progressive cognitive decline, particularly in patients with type 2 diabetes mellitus. Evidence shows that HbA1c reflects shared pathophysiological mechanisms between both conditions, such as oxidative stress, neuroinflammation, and cerebral vascular dysfunction. In addition to its predictive accuracy, HbA1c has practical advantages due to its low cost and clinical availability. The results suggest that this test should be considered a complementary tool in dementia prevention and screening strategies. The integration between endocrinology and neurology becomes essential for a more effective and earlier clinical approach to neurodegenerative disease progression.
- João Gabriel Mello de Almeida
- Ramon Fraga de Souza Lima