EXPLORANDO O POTENCIAL DA PSILOCIBINA COMO TERAPIA INOVADORA PARA DEPRESSÃO: UMA REVISÃO DE EVIDÊNCIAS CIENTÍFICAS.
EXPLORANDO O POTENCIAL DA PSILOCIBINA COMO TERAPIA INOVADORA PARA DEPRESSÃO: UMA REVISÃO DE EVIDÊNCIAS CIENTÍFICAS.
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DOI: https://doi.org/10.22533/at.ed.7161525180610
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Palavras-chave: PALAVRAS-CHAVE: “Psilocibina”; “Transtornos Depressivos”; “Tratamento para Transtorno Depressivo Resistente”; “Antidepressivos”; “Terapia Psicodélica Assistida”; “Experiência Mística”.
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Keywords: KEYWORDS: "Psilocybin"; "Depressive Disorders"; "Treatment for Resistant Depression"; "Antidepressants"; " Psychedelic Assisted Therapy"; "Mystical Experience".
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Abstract: Psilocybin, an alkaloid found in mushrooms, has attracted increasing interest due to its therapeutic potential, especially in the treatment of mental disorders such as resistant depression. Despite the evidence on its antidepressant benefits, there are gaps in the literature that require further investigation. This integrative review adopted a qualitative, retrospective and cross-sectional approach, examining 685 articles, selecting 19 for analysis, using databases such as Cochrane Library and PubMed. Of the studies analyzed, 89.47% showed positive results, indicating efficacy in relieving depression symptoms. The safety of psilocybin was explored, showing mild and transient adverse effects in some cases. The favorable safety profile was highlighted. The analysis revealed positive correlations between psychedelic experiences and therapeutic results in 68.42% of the studies. However, methodological gaps, such as the absence of control groups, were identified. This review highlights the evolution in understanding the therapeutic potential of psilocybin for resistant depression. Offering a critical view of the current state of research, which leads to future directions. We highlight the need for more robust and comprehensive studies to fully understand the role of psilocybin in the challenging therapy of treatment-resistant depression.
- Moniquy Quintela Orlando de Moraes
- Beatriz Bertin Gomes
- Leticia Monteiro Gomes
- Natália Moura Requeijo
- Nardo da Silva Ouriques