EFICÁCIA, SEGURANÇA E IMPACTO DA DAPAGLIFLOZINA EM INSUFICIÊNCIA CARDÍACA, DOENÇA RENAL CRÔNICA E DIABETES TIPO 2: UMA REVISÃO INTEGRADA DE ESTUDOS CLÍNICOS (2020-2024)
EFICÁCIA, SEGURANÇA E IMPACTO DA DAPAGLIFLOZINA EM INSUFICIÊNCIA CARDÍACA, DOENÇA RENAL CRÔNICA E DIABETES TIPO 2: UMA REVISÃO INTEGRADA DE ESTUDOS CLÍNICOS (2020-2024)
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DOI: https://doi.org/10.22533/at.ed.59924211122
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Palavras-chave: Insuficiência cardíaca; Doença renal crônica; Diabetes tipo 2.
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Keywords: Heart failure; Chronic kidney disease; Type 2 diabetes.
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Abstract: Dapagliflozin, an SGLT2 inhibitor initially developed for type 2 diabetes, has shown significant benefits beyond glycemic control, especially in heart failure and chronic kidney disease. Studies like DAPA-HF and DAPA-CKD demonstrate its efficacy in reducing hospitalizations and disease progression, both in diabetic and non-diabetic patients. Besides improving cardiac and renal function, dapagliflozin enhances quality of life, with minimal adverse effects. The 10 mg/day dose is the most effective, with a favorable safety profile. This review of studies from 2020 to 2024 emphasizes dapagliflozin’s role in treating chronic conditions and highlights its potential for expanded applications.
- Maria Eduarda Guimarães Porto