The degradation of Rhodamine B dye in water was experimentally studied under two advanced oxidation processes, using ultraviolet light and ultrasound irradiation, in the presence of TiO2 catalyst. The effect of operational variables affecting the photocatalytic and sonocatalytic processes were studied, including catalyst loading, pH, and addition of H2O2 as an oxidizing agent. The optimal operating conditions for higher dye degradation corresponded to ca. 0.5 g L-1 catalyst concentration, and pH=2.5, for both photocatalytic and sonocatalytic processes. These experimental conditions were then considered to evaluate a possible synergy by combining both technologies, which showed that combination of both technologies exceed the degradation of each technology separately.