EFEITOS RENOPROTETORES DO ENALAPRIL NA HIPERTENSÃO ARTERIAL: UMA ANÁLISE ABRANGENTE DOS BENEFÍCIOS TERAPÊUTICOS E POSSÍVEIS COMPLICAÇÕES

• DOI: https://doi.org/10.22533/at.ed.4682412041

• Palavras-chave: Enalapril, Proteção renal, Hipertensão Arterial, Inibidor da angiotensina II.

• Keywords: Enalapril, Renal Protection, Arterial Hypertension, Angiotensin II Inhibitor.

• Abstract: The chapter addresses the relationship between systemic arterial hypertension (SAH) and renal diseases, with emphasis on the role of enalapril in renal protection. Using a methodology of literature review, searches were conducted on scientific platforms to identify relevant studies on the subject. The results indicate that enalapril, an angiotensin-converting enzyme inhibitor (ACEI), has significant nephroprotective properties, reducing intraglomerular pressure, proteinuria, and renal inflammation. ACEIs, such as enalapril, have been considered effective in the treatment of arterial hypertension, especially in individuals with elevated renin. Despite their therapeutic benefits, they may cause adverse effects such as hypotension, dry cough, and angioedema. However, most of these effects are considered mild. The conclusion highlights the importance of enalapril in the clinical management of chronic kidney disease (CKD), preventing its progression and reducing the risk of renal complications. However, further research is needed to fully understand its benefits and risks, as well as to identify subgroups of patients who may benefit most from this therapy. The chapter emphasizes the relevance of understanding the mechanism of action of enalapril and its relationship with renal protection in hypertensive patients, aiming to improve the well-being and health outcomes of these patients. This information can guide the development of new therapeutic strategies and improve the prognosis of patients with CKD.