EARLY EVALUATION OF HORMONAL, SEMINAL AND FUNCTIONAL SURGERY

• DOI: https://doi.org/10.22533/at.ed.3742516017

• Palavras-chave: EARLY EVALUATION OF HORMONAL, SEMINAL AND FUNCTIONAL SURGERY

• Keywords: EARLY EVALUATION OF HORMONAL, SEMINAL AND FUNCTIONAL SURGERY

• Abstract:

  Background: Obesity is being considered a global epidemic. This condition is associated to diabetes, cardiac dysfunctions and fertility problems. The treatment indicated to obese people (degree 3) is the bariatric surgery which in long term improves some physiological alterations including male reproductive aspects; but the early consequences of BMI reduction in male fertile potential still unknown. Objectives: To verify the early weight loss effects resulting from bariatric surgery in obese men in sexual hormonalprofile, seminal parameters, sperm functional features and seminal lipid peroxidation levels Materials and methods: Patients who had a bariatric surgery indication made available blood and seminal sample to two analysis moments: before the surgery and 90 days after the procedure. The obtained blood samples were used to the hormonal profile analysis and, with the seminal sample, the conventional seminal analysis was performed, besides sperm DNA integrity evaluation, sperm mitochondrial activity analysis and evaluation of lipid peroxidation. Results: After 90 days of the surgery, the body weight and consequently the BMI considerably decreased; moreover, the total testosterone levels improved and estradiol was decreased. In relation to semen analysis, just the round cell parameter showed significant results with amount reduced. No significant results were found in the sperm DNA integrity, sperm mitochondrial activity and lipid peroxidation levels. Lastly, correlation analysis showed a positive correlation between BMI and estradiol and BMI and round cells. Discussion and Conclusion: Knowing the moment when the overweight loss begins to improve the fertile potential of obese men supports a better and organized clinical management for his reproductive treatment. Thus, we concluded that the early weight loss resulting from the bariatric surgery is already sufficient to positively modify the hormonal profile and the seminal quality of the obese man; however, it is not enough to improve the sperm functional quality.