Consumo de Leite A2 na Intolerância à Lactose: uma revisão sobre seus efeitos no desconforto gastrointestinal
Consumo de Leite A2 na Intolerância à Lactose: uma revisão sobre seus efeitos no desconforto gastrointestinal
DOI: https://doi.org/10.22533/at.ed.531112505031
Palavras-chave: Leite A2; Intolerância à lactose, β-caseína A2; Saúde digestiva.
Keywords: A2 milk; Lactose intolerance, A2 β-casein; Digestive health.
Abstract: Cow's milk plays an important role in human nutrition due to its valuable nutritional composition, which contributes to growth, development, disease prevention and a balanced healthy diet. Recent studies suggest that consumption of milk containing β-casein A1 is associated with gastrointestinal disorders, such as lactose intolerance and inflammatory processes. However, interest in A2 milk has grown in recent years, driven by discussions about its beneficial effects for lactose intolerant individuals. This study aims to investigate the effects of A2 milk consumption on lactose intolerance, analyzing the biochemical characteristics and the relationship with symptoms of gastrointestinal discomfort. For this, a bibliographic survey was carried out in the Scopus, MEDLINE/Pubmed, Web of Science, Science Direct and Embase databases, considering studies between 2014 and 2024 and following search equations for each database. A2 milk contains only A2 β-casein and is distinguished by the presence of the amino acid proline at position 67 and releases β-casomorphin-9 in the digestive process. The clinical trials analyzed indicate that A2 milk can reduce gastrointestinal symptoms, such as abdominal pain and bloating, flatulence, borborygmus, fecal urgency and constipation, when compared to milk containing A1 β-casein. However, the results are not yet conclusive enough to widely recommend A2 milk as a substitute for individuals with lactose intolerance.
- Lídia Regina Tavares Silva
- Uliana Karina Lopes de Medeiros