CONHECENDO AS LEUCEMIAS DA CLÍNICA A LEITURA DE LÂMINA: UMA REVISÃO LITERÁRIA
CONHECENDO AS LEUCEMIAS DA CLÍNICA A LEITURA DE LÂMINA: UMA REVISÃO LITERÁRIA
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DOI: https://doi.org/10.22533/at.ed.6191225020110
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Palavras-chave: Leucemia, Diagnóstico laboratorial, Células-tronco, Tratamento, Hematopoiese
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Keywords: Leukemia, Laboratory diagnosis, Stem cells, Treatment, Hematopoiesis
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Abstract: Leukemia is a malignant neoplasm of the hematopoietic system characterized by the uncontrolled clonal proliferation of pluripotent stem cells. Leukemias are classified as acute and chronic, and subdivided into lymphoid and myeloid. Acute Myeloid Leukemia (AML) is common in adults and characterized by the rapid proliferation of myeloid blasts. Acute Lymphoid Leukemia (ALL) mainly affects children and is marked by the uncontrolled proliferation of lymphoblasts. Chronic Myeloid Leukemia (CML) is characterized by the presence of the Philadelphia chromosome and is divided into three phases: chronic, accelerated, and blast crisis. Chronic Lymphoid Leukemia (CLL) is a malignancy of mature B cells, with slow progression, but which can evolve into aggressive lymphomas. Laboratory diagnosis includes complete blood count, bone marrow count, immunophenotyping by flow cytometry, FISH and PCR techniques, and Next Generation Sequencing (NGS). Treatments vary according to the type and stage of leukemia, including chemotherapy, targeted therapy, and stem cell transplantation. Early diagnosis and effective follow-up are essential to improve the prognosis and quality of life of patients. Leukemia is a serious public health problem worldwide, with high morbidity and mortality. Early identification and appropriate treatment are crucial for patient survival.
- José Weverton Almeida Bezerra
- Julia Oliveira do Nascimento
- Ana Ruth Sampaio Granjeiro
- Gustavo Marinho Miranda
- Murilo Felipe Felício
- Eveline Naiara Nuvens Oliveira
- Naiana Silva Guedes
- Janaína de Souza Bezerra
- Francisca de Fátima Silva de Sousa
- Luciene Ferreira de Lima
- Rita Helanny Viana Eugenio
- José Walber Gonçalves Castro