COMPARAÇÃO ENTRE OS INIBIDORES DE SGLT2: O QUE DIFERENCIA A DAPAGLIFLOZINA DAS OUTRAS OPÇÕES?
COMPARAÇÃO ENTRE OS INIBIDORES DE SGLT2: O QUE DIFERENCIA A DAPAGLIFLOZINA DAS OUTRAS OPÇÕES?
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DOI: https://doi.org/10.22533/at.ed.842162512066
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Palavras-chave: Dapagliflozina; inibidores SGLT2; tratamento cardíaco; doença renal; comparação terapêutica.
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Keywords: Dapagliflozin; SGLT2 inhibitors; heart treatment; kidney disease; therapeutic comparison.
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Abstract: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have increasingly gained relevance not only in managing type 2 diabetes but also in treating complex conditions such as heart failure and chronic kidney disease. This paper reviews and contrasts the main agents within this class, particularly dapagliflozin, empagliflozin, canagliflozin, and ertugliflozin, highlighting distinctions that influence their use in real-world clinical settings. Among them, dapagliflozin emerges as a more balanced and favorable option due to its high SGLT2 selectivity, lower risk of adverse events, and well-established effectiveness across various patient profiles. Additionally, its cost-effectiveness reinforces its value in resource-constrained health systems. This analysis supports safer and more personalized treatment decisions rooted in scientific evidence.
- Leandro de Oliveira Reckel
- Filipe Flores Bicalho
- Dayra Fieni
- Lucas de Brito Machado
- Bruno Pereira dos Santos
- Wagner de Brito Veras