COMPARAÇÃO DA EFICÁCIA E SEGURANÇA DOS ANTICOAGULANTES ORAIS DIRETOS E WARFARINA EM FIBRILAÇÃO ATRIAL: REVISÃO DE LITERATURA
COMPARAÇÃO DA EFICÁCIA E SEGURANÇA DOS ANTICOAGULANTES ORAIS DIRETOS E WARFARINA EM FIBRILAÇÃO ATRIAL: REVISÃO DE LITERATURA
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DOI: https://doi.org/10.22533/at.ed.7352413111
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Palavras-chave: Apixabana; warfarin, tratamento.
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Keywords: Apixaban; warfarin; treatment.
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Abstract: Apixaban is a widely used oral anticoagulant for the prevention of thromboembolic events in patients with atrial fibrillation (AF) and venous thromboembolism (VTE). Its action directly inhibits factor Xa, eliminating the need for constant monitoring, such as INR required for warfarin. Studies have demonstrated that apixaban significantly reduces the risk of stroke, systemic embolism, and major bleeding compared to warfarin, particularly in vulnerable populations like the elderly and patients with renal impairment. Additionally, apixaban proves effective in various clinical contexts, such as in combination with antithrombotic therapies and in revascularization procedures. Although its direct cost is higher, its cost-effectiveness is highlighted by reducing hospitalizations and complications. In summary, apixaban is a valuable and safe option for anticoagulation management in various patient subgroups, offering a balance between efficacy, safety, and practicality.
- Estevao Ferreira de Oliveira Lucas
- Gabriel Fontanezi Campos Albuquerque
- Ramon Fraga de Souza Lima