In the 21st century, higher education faces a series of challenges and opportunities in an increasingly digitalized and connected world. Digital education and media inclusion have become two key aspects to ensure a comprehensive and equitable education in this context. Therefore, university education in the 21st century must be disruptive and transformative. Its goal should focus on preparing students to face the challenges and opportunities of a digitalized world. It should help them develop skills and abilities to navigate a reality that is constantly changing and, to some extent, uncertain. In this regard, digital education and media inclusion become powerful tools to achieve this objective. Through comprehensive training that integrates technology, media literacy, and critical thinking, higher education institutions can cultivate informed, responsible, and participative citizens.