Candidíase Oral: Revisão sobre a patogenicidade de Candida albicans, Tratamentos Convencionais e Nova Alternativa Terapêutica com Enfoque em Bauhinia holophylla (Bong.) Steud.
Candidíase Oral: Revisão sobre a patogenicidade de Candida albicans, Tratamentos Convencionais e Nova Alternativa Terapêutica com Enfoque em Bauhinia holophylla (Bong.) Steud.
-
DOI: https://doi.org/10.22533/at.ed.9602422071
-
Palavras-chave: Candida albicans; Candidíase oral; Novas terapias; Bauhinia holophylla (Bong.) Steud.
-
Keywords: Candida albicans; Oral candidiasis; New therapies; Bauhinia holophylla (Bong.) Steud.
-
Abstract: Candida albicans is the main pathogenic agent causing oral candidiasis, considered a public health problem affecting a large part of the population. Topical conventional treatments with nystatin and chlorhexidine gluconate have side effects and toxicity, driving the search for therapeutic alternatives. In this scenario, medicinal plants emerge as a rich possibility for the development of antifungal agents capable of acting in the treatment of oral candidiasis. Bauhinia holophylla (Bong.) Steud., known as "cow's paw," belongs to the Fabaceae family and is popularly used to treat infections and inflammatory processes; however, its antifungal potential is still poorly understood. Thus, this study aimed to review the literature on Candida albicans, its virulence factors, association with oral candidiasis, treatments, and therapeutic alternatives, with emphasis on researching the antifungal activity of B. holophylla. Scientific article research was conducted in the PubMed, Scielo, and ScienceDirect databases, using the terms: "Candida albicans AND virulence factors", "Oral candidiasis AND conventional treatments AND new alternatives", "Bauhinia holophylla AND morphology AND popular use AND antifungal potential”. The findings highlight the complexity of oral candidiasis and the challenges of conventional treatment due to resistance to antifungals and their associated side effects. In this sense, therapeutic alternatives such as plant extracts, especially those from Bauhinia holophylla, show promising potential due to their chemical constituents; however, further research is needed to understand their mechanisms of action and possible applications, aiming for safer and more effective therapies to promote the quality of life of individuals with oral candidiasis.
- João Víctor de Andrade dos Santos
- Stéfani de Oliveira Rosa
- Cleison da Rocha Leite
- Mariane da Silva
- Mariane da Silva Fagundes
- Adriana Araújo de Almeida-Apolonio
- Diana Liz Jimenez Rolão
- Fabiana Gomes da Silva Dantas
- Kelly Mari Pires de Oliveira