BONE TURNOVER MARKERS IN SHEEP AND GOAT: A REVIEW OF THE SCIENTIFIC LITERATURE

• DOI: 10.22533/at.ed.1771920064

• Palavras-chave: Atena

• Keywords: Bone formation markers; bone resorption markers; bone metabolism; small ruminants

• Abstract:

  Bone turnover markers (BTMs) are product of bone cell activity and are

  generally divided in bone formation and bone resorption markers. The purpose of this

  review was to structure the available information on the use of BTMs in studies on small

  ruminants, especially for monitoring their variations related to diet, exercise, gestation

  and metabolic lactation state, circadian and seasonal variations, and also during skeletal

  growth. Pre-clinical and translational studies using BTMs with sheep and goats as

  animal models in orthopaedic research studies to help in the evaluation of the fracture

  healing process and osteoporosis research are also described in this review. The

  available information from the reviewed studies was systematically organized in order

  to highlight the most promising BTMs in small ruminant research, as well as provide a

  wide view of the use of sheep and goat as animal models in orthopaedic research, type

  of markers and commercial assay kits with cross-reactivity in sheep and goat, method

  of sample and storage of serum and urine for bone turnover markers determination

  and the usefulness and limitations of bone turnover markers in the different studies,

  therefore an effective tool for researchers that seek answers to different questions

  while using BTMs in small ruminants. [“Title: Bone turnover markers in sheep and

  goat: A review of a scientific literature. Authors: José A. Camassa, Camila C. Diogo,

  Cristina P. Sousa, Jorge T. Azevedo, Carlos A. Viegas, Rui L. Reis, Nuno Dourado and

  Isabel R. Dias. An Acad Bras Cienc. March (2017) 89(1): 231-245.”]

• Número de páginas: 15