AVANÇOS TERAPÊUTICOS NA INSUFICIÊNCIA CARDÍACA: PAPEL DOS INIBIDORES DO COTRANSPORTADOR SÓDIO-GLICOSE TIPO 2 (SGLT2)
AVANÇOS TERAPÊUTICOS NA INSUFICIÊNCIA CARDÍACA: PAPEL DOS INIBIDORES DO COTRANSPORTADOR SÓDIO-GLICOSE TIPO 2 (SGLT2)
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DOI: https://doi.org/10.22533/at.ed.656122624036
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Palavras-chave: Insuficiência Cardíaca; Inibidores de SGLT2; Empagliflozina; Dapagliflozina; Desfechos Cardiovasculares.
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Keywords: Heart Failure; SGLT2 Inhibitors; Empagliflozin; Dapagliflozin; Cardiovascular Outcomes.
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Abstract: Introduction: Heart failure remains one of the leading causes of cardiovascular morbidity and mortality worldwide. Recently, sodium–glucose cotransporter 2 (SGLT2) inhibitors have emerged as an important therapeutic strategy in the management of this condition. Objective: To analyze the scientific evidence regarding the effects of SGLT2 inhibitors in the treatment of heart failure. Methods: A systematized literature review based on PRISMA guidelines was conducted using studies published between 2020 and 2025 in PubMed, SciELO, and LILACS databases. Results: The analyzed studies demonstrated that SGLT2 inhibitors reduce heart failure hospitalizations, decrease cardiovascular mortality, and provide additional renal and metabolic benefits. Conclusion: SGLT2 inhibitors represent an important therapeutic advance in heart failure treatment, expanding available pharmacological strategies and improving patient outcomes.
- João Victor De Carvalho Silva Corrêa
- Natália Barreto e Sousa